DMT is a natural chemical found in some Amazonian plant species but it can also be chemically synthesized. It usually comes as a white, crystalline powder that is vaporized or smoked in a pipe or bong.
It is typically consumed in the following ways:
- vaporized or smoked in a pipe
- consumed orally in brews like ayahuasca
- snorted or injected on rare occasions
The chemical root structure of DMT is similar to the anti-migraine drug sumatriptan, and it acts as a non-selective agonist at most or all of the serotonin receptors, particularly at the serotonin 5-ht2a receptor. Serotonin is a neurotransmitter that has a large effect on the majority of our brain cells. When smoked, the average dose of DMT is believed to be somewhere between 30 to 150 milligrams (mg), and the onset of action can be felt almost instantly.
The effects peak and plateau for 3 to 5 minutes, and gradually drop off with the duration of effect totaling 30 to 45 minutes.
When smoked, DMT produces brief yet intense visual and auditory hallucinations that have been described by users as an alternate reality, otherworldly, or a near-death experience.
Possible side effects of DMT include:
- increased heart rate
- increased blood pressure
- chest pain or tightness
- dilated pupils
- rapid rhythmic movements of the eye
In comparison to other psychedelic drugs, such as LSD, MDMA, and magic mushrooms, recreational users of DMT consider it to have the lowest side effect profile- Dmt experiences-